Weight Gain, Atherosclerosis, Diabetes Relationship

Weight Gain, Vascular disease, Diabetes Relationship

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    This article in issue deals with plenty of effects of in depth diabetes treatment found in type 1 diabetic patients. Purnell ou al. (2012) state that intensive diabetic treatment have been deemed as an successful solution to address diabetic type 1 signs, nonetheless it is also related with quite significant side effects. Typically the authors focus about the introduction of atherosclerosis, since well as additional health issues, associated together with type 1 diabetic (T1DM) intensive remedy. The objective regarding the analysis is to check out the relationships in between regarding metabolic problem, excessive weight increase, atherosclerosis, and in depth diabetes treatment. Purnell et al. (2012) hypothesize that lipids and hypertension, since well as typically the family history regarding T2DM, is connected with “worsening markers regarding atherosclerosis” in sufferers during intensive diabetic treatment (p. 180).

    Typically the authors used a new longitudinal experimental analysis design to look at their hypothesis. Sufferers were divided directly into two groups: individuals who received a rigorous or conventional sort 1 diabetes remedy. Purnell et ‘s. (2012) state of which the final results of typically the study show of which there is a great obvious correlation in between intensive T1DM remedy, excessive fat gain, in addition to T2DM histories. Typically the major dependent parameters used were hypotension, lipid levels, in addition to waist circumference.


    It is definitely possible to be aware that the study beneath analysis is somewhat effective, nonetheless it may be improved in several ways. For example, Purnell et al. (2012) tend not to include a new literature review part. The authors relate to other scientific studies, but these work references are rather rare. These are included found in the introduction in addition to discussion sections. Nevertheless, the absence regarding the literature overview the actual study pretty disconnected from typically the overall knowledge basic on the make a difference. The reader does indeed not have good enough details to know the scope regarding knowledge with regards to the outcomes of intensive sort 1 diabetes remedy. It is likewise unclear whether or not the concern has attracted virtually any attention of students in addition to practitioners.

    At the similar time, it is easy to take note that the analysis is current in addition to strongly related current well being issues. First, typically the article was posted in 2012 following the experiments got been carried out there. The subject is relevant simply because there are lots of people suffering from sort 1 diabetes who else receive different varieties of treatment seen as benefits and significant side effects. As a result, it is crucial to check out the effects regarding a number of00 treatment to be able to ensure the finest outcomes for sufferers.

    As much as the type regarding research is involved, it is successful and relevant to be able to the study’s objective. Purnell et ‘s. (2012) utilize the trial and error research design to be able to check their speculation. The authors look at the effects (particular variables) of typically the intensive T1DM remedy and the regular one. It is usually also noteworthy of which the dependent parameters used are strongly related the objective since well since blood vessels pressure, lipid ranges, and waist area can reveal the level of weight gain in addition to regarding atherosclerosis.

    It is usually possible to take note that the trial is one regarding the strengths regarding the study. The quantity of participants is considerable and can get regarded as helpful enough as 1940 participants took portion in the examine. As has recently been mentioned above, typically the participants were split up into two groups at random (1015 and 925), which makes typically the comparison relevant considering that the number of individuals found in each group is usually quite similar. Randomly sampling ensured typically the validity of typically the research. It is usually possible to express that the trial was appropriate to be able to the research because the participants had related health conditions, thus the within their particular health could possibly be in contrast.

    One more important strength in the research is it may be being practical. Purnell et al. (2012) provide scientific research of the connection between intensive T1DM treatment and too much weight gain and also the development of vascular disease symptoms. The copy writers stress that T2DM family histories likewise correlate with typically the development of signs in T1DM sufferers who receive in depth T1DM treatment. This info can help scientists inside the development regarding more effective procedures when treating typically the disorder and taking into consideration such criteria since family histories. Typically the researchers note of which their study allows practitioners to pick appropriate treatment varieties as it is usually clear that extensive T1DM treatment may possibly lead to significant side effects. Purnell et al. (2012) include that that is critical paying more attention to be able to weight loss in these kinds of patients as it can prospect to improved well being outcomes. I help the researchers’ concepts concerning the functional technique article.

    As provides been stated earlier, typically the research is pretty effective, but any time considering possible advancements, it is potential to increase based mostly variables to try. That has been identified that diabetes is usually a disorder of which is associated with certain lifestyles. Therefore, it can be important to add the amount of exercise the participants have and their dietary habits. The experiment could be improved through the use of a survey that would include the points mentioned above. It can also be effective to highlight such aspects as socio-economic status and employment. People having more funds can have healthier lifestyles as they can afford better food and have more leisure time that can be devoted to exercise.

    As to the downsides of the articles, it is possible to note that the writing is quite effective, but the layout of the article could be improved. For example , the authors should provide tables and graphs in the text as it is not very convenient to read the result section and search for the necessary page each time it is needed. The results section is overloaded with numbers, which makes it quite difficult to follow.

    Although this study provides valuable insights into the topic, there are still numerous gaps yet to be addressed. For instance, it is possible to explore the correlation between intensive T1DM treatment in patients about different age or ethnic groups. The study in question involves predominantly Caucasians, but ethnicity may have a certain effect on the way the disorder develops.


    In conclusion, it is possible to note that the article in question can be regarded as a valuable resource for those interested in the peculiarities of T1DM treatment. The study provides insights into the way intensive treatment correlates with excessive weight gain and the development of atherosclerosis. However, further research can complete the remaining gaps. For example , such factors as socioeconomic status and ethnicity can be analyzed. More so, the way the results of the research are delivered could also be improved. The article would benefit from the use of such sections as the literature review, limitations, and implications. The researchers could improve their results section through the use of graphs in the text as compared to using them in appendices.


    Purnell, J. Q., Hokanson, J. E., Cleary, P. A., Nathan, D. M., Lachin, J. M., Zinman, B., & Brunzell, J. (2012). The effect of excess weight gain with intensive diabetes treatment on cardiovascular disease risk factors and atherosclerosis in type 1 diabetes: Results from the diabetes control and complications trial / epidemiology of diabetes interventions and complications study (DCCT/EDIC) Study. Circulation , 127 (2), 180-1

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